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In the SURMOUNT-5 trial, tirzepatide produced an average weight reduction of 20.2% (about 50 lbs) over 72 weeks, compared with 13.7% (about 33 lbs) for injectable semaglutide
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102 This is done by reducing IL-6, inhibiting B cell, T cell, and Natural Killer (NK) cell activation, as well as decreasing M1 and enhancing M2 activation
Some people do not produce enough natural GLP-1 which makes weight loss much harder
Sanchez, T
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